PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4095)
Related Products (4095)
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PROTAC Linkers Isoform Comparison
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((3-Bromopropoxy)methyl)benzene
0 ImagesCat. No.: HY-W001590CAS No.: 54314-84-0
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4-Bromo-1-trimethylsilyl-1-butyne
0 ImagesCat. No.: HY-W092986CAS No.: 69361-41-7
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1-Chloro-3-(3-chloropropoxy)propane
0 ImagesCat. No.: HY-W111175CAS No.: 629-36-7
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8-Amino-1-octanol
0 ImagesSynonyms: NH2-(CH2)7-COOH
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tert-Butyl (3-(methylamino)propyl)carbamate
0 ImagesCat. No.: HY-40177CAS No.: 442514-22-9
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4-Bromobutoxy-tert-butyl-dimethylsilane
0 ImagesCat. No.: HY-W093128CAS No.: 89043-32-3
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p-(Methoxycarbonylmethyl)aniline
0 ImagesCat. No.: HY-W019294CAS No.: 39552-81-3
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Fmoc-7-amino-heptanoic acid
0 ImagesCat. No.: HY-W009056CAS No.: 127582-76-7Fmoc-7-amino-heptanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. Fmoc-7-amino-heptanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
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TCO-PEG3-amine
0 ImagesCat. No.: HY-141178CAS No.: 1800507-93-0
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Iodoacetamide-PEG3-azide
0 ImagesIodoacetamide-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Iodoacetamide-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Azido-PEG8-acid
0 ImagesAzido-PEG8-acid is a non-cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG8-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG8-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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TCO-PEG12-NHS ester
0 ImagesCat. No.: HY-141170CAS No.: 2185016-39-9TCO-PEG12-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG12-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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Amino-PEG6-amine
0 ImagesCat. No.: HY-23105CAS No.: 76927-70-3
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Azide-PEG4-Tos
0 ImagesAzide-PEG4-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG4-Tos is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Propargyl-PEG5-OH
0 ImagesCat. No.: HY-130147CAS No.: 1036204-60-0
